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What Does Running on a Treadmill Do For Your Body? · An elliptical trainer targets the lower body in much the same way that a treadmill does but with the advantage of being able to simultaneously work the muscles of the arms, chest and back. You can also consider using a full-body workout machine though you will still need to do some form of cardio. What Walking on a Treadmill Does to Your Body, Say Experts · You'll work these muscle groups. "Walking on a treadmill works several parts of your body, including your ankles, glutes, hamstrings, quads, and core—and,…